Keywords
Abstract
This article describes the outcome of an experimental study of the bioactive glass use in combination with the antibiotic amoxicillin for osteoplasty of bone defects with an endoparodontal focus of infection. For this purpose, we created an artificial defect in a tibial bone of rabbits, which was filled with a combination of bioactive glass and the antibiotic amoxicillin. The results of the experiment of tibial bone artificial defect plasty with bioactive glass and antibiotic carried out in stages for 1, 2, and 3 months. The experiment showed that the signs of ossification and repair occur much more effectively already in the second month. In the third month of the experiment, a macroscopic study showed the new bone tissue at the site of the artificial defect is smooth, without tuberosity and does not differ from normal tissue on the incision. Histologically, there were also no signs of deformation, the boundary of the new bone at the defect area and normal bone tissue is not defined and contain a large number of osteocytes.
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