CHANGES IN VITAMIN D CONTENT DURING THE DEVELOPMENT OF EXPERIMENTAL ATHEROSCLEROSIS AND WAYS OF ITS CORRECTION

Abstract

This article examines changes in vitamin D levels during the development of experimental atherosclerosis and approaches to its correction. The results showed that as atherosclerosis progressed, vitamin D levels decreased, reaching a minimum on the 60th day of the experiment (4.9 ± 0.5 ng/ml). In animals that received Levazo, vitamin D levels increased, whereas in groups treated with Thiocin, its levels decreased. However, higher doses of Thiocin (70 mg/kg) improved liver function, which contributed to better vitamin D metabolism. The combined administration of Levazo and Thiocin partially prevented the decline in vitamin D levels. Thus, statins may reduce vitamin D levels, but Thiocin, due to its hepatoprotective effect, partially compensates for this effect. Therefore, the combination of statins and Thiocin may be more effective in the treatment of atherosclerosis.