LABORATORY ANALYSIS OF MALONDIALDEHYDE INDICATOR IN COXARTHROSIS OF THE HIP JOINT AND OSTEONECROSIS OF THE FEMORAL HEAD IN MILITARY PERSONNEL
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Keywords

malondialdehyde, coxarthrosis, osteonecrosis, peroxide oxidation, lipid, hip joint, femoral head

Abstract

In this work, the results of analysis of malondialdehyde (MDA) value of lipid peroxidation index in coxarthrosis and osteonecrosis of the femoral head are presented. The average value of the amount of malondialdehyde in the blood of healthy people was 1.2 times higher (22.9%) compared to the value found in patients treated for coxarthrosis of the hip joint. In patients treated with osteonecrosis of the femoral head, this value was found to be 1.6 times (63.9%) higher than the average value found in the control group. In erythrocytes of patients with coxarthrosis of the hip joint, this value is 1.3 times (29.7%) higher than in the control group, and in patients with osteonecrosis of the femoral head, it is 1.7 times (72.7%) higher than in the control group it happened.

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References

Augustine J., Troendle E. P., Barabas P. et al. The role of lipoxidation in the pathogenesis of diabetic retinopathy//Front Endo-crinol., 2020. - N11. - Р.621-938.

Bayjanov A. K., Muxitdinova I. R., Ibragimova N. X. Selected laboratory parameters for COVID-19-associated aseptic necrosis of the hip joint in military personnel / Multidiscipline Proceedings of "Digital fashion conference", Korea, November, 2023. - Volume 3, - N 6. – р. 7-8. https://www.digitalfashionsociety.org/index.php/conference/article/view/214/210.

Castro J. P., Jung T., Grune T. et al. 4-Hydroxynonenal (HNE) modified proteins in metabolic diseases // Free Radic Biol Med., 2017. - N 111. - Р. 309-15.

Di Meo S., Reed T. T., Venditti P. et al. Role of ROS and RNS sources in physiological and pathological conditions // Oxid Med Cell Longev., 2016. – N 124. - Р. 1245-049.

Franz A., Joseph L., Mayer C. et al. The role of oxidative and nitrosative stress in the pathology of osteoarthritis: novel candi-date biomarkers for quantification of degenerative changes in the knee joint // Orthop Rev Pavia, 2018. - N 10. - Р. 7460.

Gianazza E., Brioschi M., Fernandez A. M. et al. Lipoxidation in cardiovascular diseases // Redox Biol., 2019. - N 23. - Р. 101-119.

Gianazza E., Brioschi M., Martinez A. et al. Lipid peroxidation in atherosclerotic cardiovascular diseases // Antioxid Redox Signal., 2021. - N34. - Р. 49-98.

Hines M., Gomez-Contreras P. C., Rodman S. et al. Lipid perox-idation regulates chondrocyte mitochondrial dynamics and cartilage injuryresponse // Free Radic Biol Med., 2022. - N 180:s. - Р. 22.

Jovе M., Mota-Martorell N., Pradas I. et al. The advanced lipoxidation end-product malondialdehyde-lysine in aging and long-evity. Antioxidants Basel., 2020. - N 9. - Р. 11-32.

Li Y., Feng D., Wang Z. et al. Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia reperfusion // Cell Death Differ., 2019. - N26. - Р. 2284-99.

Miao Y., Chen Y., Xue F. et al. Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression. EbioMedicine, 2022. - N 76. - Р. 103-847.

Mo Z., Xu P., Li H. Stigmasterol alleviates interleukin-1beta-induced chondrocyte injury by down-regulatingsterol regulatory element binding transcription factor 2 to regulateferroptosis. Bioengineered., 2021. - N 12. - Р. 9332-40.

Mol M., Regazzoni L., Altomare A. et al. Enzymatic and non-enzymatic detoxification of 4-hydroxynonenal: methodological aspects and biological consequences // Free Radic Biol Med., 2017. - N 111. - Р. 328-44.

Martín-Sierra C., Laranjeira P., Domingues M. R. et al. Lipoxidation and cancer immunity // Redox Biol. 2019. - N 23. - Р. 101-103.

Mas-Bargues C., Escrivа C., Dromant M. et al. Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease // Arch Biochem Biophys., 2021. - N 709. - Р. 108941.

Pinazo M. D., Gallego R., Garcia J. J. et al. Oxidative stress and its downstream signaling in aging eyes // Clin Interv Aging., 2014. - N 9. - Р. 637-52.

Peña-Bautista C., Vento M., Baquero M. et al. Lipid peroxidation in neurodegeneration // Clin Chim Acta., 2019. - N 497. - Р. 178-88.