THE SIGNIFICANCE OF DETERMINING HORMONES AND TUMOR MARKERS IN BLOOD SERUM IN GRANULOSA CELL TUMOR, ITS RECURRENCES AND METASTASES
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Keywords

granulosa cell tumors of the ovaries, granulosa cell tumors of the adult type ovaries, juvenile granulosa cell tumors, follicle-stimulating hormone, luteinizing hormone, inhibin A and B, estradiol, menstrual cycle

Abstract

According to Kerzhkovskaya N.S. and her colleagues, the final diagnosis of granulosa cell tumor is made only on the basis of histological examination. In addition to the standard scope of diagnostic measures, which includes general blood and urine tests, tests for markers CA-125, HE4, ROMA, CA-199, ultrasound of the abdominal organs, lung radiography, mammography, gastro- and irrigoscopy, aspiration biopsy of the endometrium, patients with If GCT is suspected, a blood test for sex steroids and inhibin, which are highly specific for this pathology, is indicated. According to indications, hysteroscopy and separate diagnostic curettage, computed tomography, laparoscopy, radioisotope study of renal function and excretory urography are performed.[5]

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References

Burger H.G.Caracterization of inhibin immunoreactivity in post-menopausal women with ovarian tumors // Clin. Endocrinol. 1996. Vol. 44. P. 413–418.

Colombo N.et al. Cisplatin, Vinblactine, and Bleomycin Combination Chemotherapy in Metastatic Granulosa Cell Tumor of the Ovary // Obstetrics and Gynecology. 1986. Vol. 67, № 2. P. 265–268

Kerzhkovskaia N.S., Zhordania K.I., Lyubimova N.V. Using inhibin-A to monitor granuloza cell tumor of the ovary // International Journal of Gynecological Cancer< 2003/ Vol. 13, suppl.1. P. 45

Margolin K.A. et al. Hepatic Metastasis in Granulosa Cell Tumor of the Ovary. // Cancer. 1985. Vol. 56. P. 691–695

К.И. Жорданина, Н.С. Кержковская, Ю.Г. Паяниди, О.А. Анурова, Н.В. Любимова ФГБУ РОНЦ им. Н.Н. Бло хи на РАМН, Москва Гранулезоклеточные опухоли яичников. Диагностика и лечение 33- 42стр.

Кержковская Н.С., Любимова Н.В., Жорданиа К.И. и др. Ингибин А, эстрадиол, ФСГ и СА-125 в диагностике и мониторинге гранулезоклеточной опухоли яичников // Современная онкология. 2003. Т. 5. С. 64–68.

Лившиц М.А. Лечение редких опухолей яичников. В сб.: Новости онкологии. Л., 1971. С. 122–125