Keywords
Abstract
The pathogenesis of rosacea remains not fully understood to date. The question remains open and debated as to how the severity and severity of the various clinical symptoms of rosacea in a particular patient can be explained. What mechanisms regulate progression of the process, leading to a combination of subtypes and a severe course in some patients and manifestation of the disease within one subtype without a tendency to worsen in others.
Purpose of the study: to study genetic markers 1298 A>C of the MTHFR gene (rs1801131), 677C>T of the MTHFR gene (rs1801133), 2756 A>G of the MTR gene (rs1805087) and 66A>G of the MTRR gene (rs1801394) in erythematous-telangiectatic and papulopustular subtypes Rosacea. Materials and methods of research. The study involved 27 people who, depending on the clinical picture of rosacea, were divided into three groups; the results were compared with 20 healthy volunteers.
References
Abram K., Silm H., Maaroos H-I. Risk factors associated with rosacea // J. EurAcad Dermatol Venereol.2010. Vol. 24. P. 565–571.
Abrams K., Silm H., Oona M. Prevalence of rosacea in an Estonian working population using a standard classification // J. Acta DermVenereol. 2010. Vol. 90. P. 269–273.
Al-Dabagh A., Davis S.A., McMichael A.J. Rosaceain skin of color: not a rare diagnosis // J. DermatolOnline. 2014.
Aldrich N., Gerstenblith M., Fu P., Tuttle M.S.,Varma P., Gotow E., Cooper K.D., Mann M.,Popkin D.L. Genetic vs. environmental factors thatcorrelate with rosacea: A cohort-based survey of twins// J. JAMA Dermatol. 2015. Vol. 151. P. 1213–1219.
Bae YI, Yun SJ, Lee JB. Clinical evaluation of 168Korean patients with rosacea: the sun exposure correlates with the erythematotelangiectatic subtype. J.Ann Dermatol. 2009;21:243-9.
Berg M., Liden S. An epidemiological study of rosacea // J Acta DermVenereol. 1989. Vol. 69. P. 419–423.
Buhl T, Sulk M, Nowak P. Molecular and morphological characterization of inflammatory infiltrate inrosacea reveals activation of Th1/Th17 pathways. J .Invest Dermatol. 2015;135:2198-208.
Chang A.L., Raber I., Xu J., Li R., Spitale R., ChenJ., Kiefer A.K., Tian C., Eriksson N.K., Hinds D.A. Assessment of the genetic basis of rosacea by genomewide association study // J. Investig. Dermatol. 2015.Vol. 135. P. 1548–1555.
Del Rosso JQ, Thiboutot D, Gallo R. Consensusrecommendations from the American Acne andRosacea Society on the management of rosacea, part 1: astatus report on the disease state, general measures,and adjunctive skin care. J. Cutis. 2013;92(5):234-40.
Del Rosso J.Q., Gallo R.L., Tanghetti E. An evaluation of potential correlations between pathophysiologic mechanisms, clinical manifestations, and management of rosacea // J. Cutis. 2013.Vol. 91(suppl3). P. 1–8.
Dlova N, Mosam A. Rosacea in black South Africans with skin phototypes V and VI. J.Clin Exp Dermatol. 2017;42:670-3.
Gomaa AHA, Yaar M, Eyada MMK, Bhawan J. Lymphangiogenesis and angiogenesis in non-phymatousrosacea.// J of CutanPathol. 2007;34(10):748–753. doi: 10.1111/j.1600-0560.2006. 00695.
Holmes A.D., Steinhoff M. Integrative concepts ofrosacea pathophysiology, clinical presentation andnew therapeutics // J. Exp Dermatol. 2017. Vol. 26.P. 659–667. 14.F Dall’Oglio, C.Fusto, G. Micali Intrafamilial Transmission of Rosacea Spanning Six Generations: A Retrospective Observational Study.//J Clin AesthetDermatol-2022 Feb;15(2):35-39
Karpouzis A, Avgeridis P, Tripsianis G, Gatzidou E. Assessment of tachykinin receptor 3′ gene polymorphism rs3733631 in rosacea. Int. Sch. Res. Not. 2015;2015:469402.
McAleer MA, Fitzpatrick P, Powell FC. The prevalence and pathogenesis of rosacea; 2008.
Palleschi GM, Torchia D. Rosacea in a monozygotic twin. Australas. J. Dermatol. 2007;:48:132-3.
Schwab V.D., Sulk M., Seeliger S. Neurovascular and neuroimmune aspects in the pathophysiology ofrosacea // J. Invest Dermatol Symp Proc. 2011.Vol. 15. P. 53–62.
Smith JR, Lanier VB, Braziel RM, Falkenhagen KM, White C, Rosenbaum JT. Expression of vascular endothelial growth factor and its receptors in rosacea. //Br J Ophthalmol. 2007;91(2):226–229. doi: 10.1136/bjo.2006.101121.
Steinhoff M, Buddenkotte J, Aubert J, Sulk M,Novak P, Schwab VD. Clinical, cellular, and molecularaspects in the pathophysiology of rosacea. J. InvestigDermatol Symp Proc. 2011;15:2-11.
Tan J., Almeida L., Bewley A. Updating the diagnosis,classification and assessment of rosacea: recommendations from the global ROSaceaCOnsensus (ROSCO)panel // J Dermatol. 2017. Vol. 176. P. 431–438.
Tan J, Blume-Peytavi U, Ortonne JP. An observational cross-sectional survey of rosacea: clinical associations and progression between subtypes. Br J Dermatol. 2013;169:555-62.
Tan J., Sch€ofer H., Araviiskaia E. Prevalence ofrosacea in the general population of Germany andRussia the RISE study // J EurAcad Dermatol Venereol. 2016. Vol. 30. P. 428–434.
Trivedi NR, Gilliland KL, Zhao W. Gene arrayexpression profiling in acne lesions reveals markedupregulation of genes involved in inflammation andmatrix remodeling. J. Invest Dermatol.2006;126:1071-9.
Weinstock L.B., Steinhoff M. Rosacea and smallintestinal bacterial overgrowth: prevalence and response to rifaximin // J. Am Acad Dermatol. 2013.Vol. 68. P. 875–876.
Wilkin J, Dahl M, Detmar M. Standard classification of rosacea: report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea. J. Am Acad Dermatol. 2002;46:584-7.
Wladis E.J., Iglesias B.V., Adam A.P. Molecularbiologic assessment of cutaneous specimens of ocularrosacea // J. OphthalPlastReconstr Surg. 2012.Vol. 28. P. 246–250.
Yamasaki K., Di Nardo A., Bardan A. Increasedserine protease activity and cathelicidin promotesskin inflammation in rosacea // J. Nat Med. 2007. Vol. 13. P. 975–980.