Abstract
The syndrome of intrahepatic cholestasis (SIC) is understood as a slowdown or cessation of bile secretion associated with changes either in its consistency (thickening) or in the lumen of the intrahepatic bile ducts (narrowing) [1–3]. Theoretically, any liver pathology can be complicated by the development of SIC, and only cases with a duration of more than 6 months are classified as chronic. Between the concepts of cholestasis and hepatic jaundice should not put an equal sign. For, the term cholestasis is a broader concept, and hepatic jaundice is just an integral part of it. Moreover, cholestasis can clinically occur with or without jaundice [4,5,6]. It is clear that both forms of cholestasis, even within the same type of liver pathology, can manifest themselves in a different form of its severity [7,8,9].
References
Ivashkin V.T. Clinical recommendations of the Russian Gastroenterological Association and the Russian Society for the Study of the Liver for the diagnosis and treatment of cholestasis / Ivashkin V.T., Shirokova E.N., Maevskaya M.V. and others // Ros. magazine tour. hepatol. coloproctol. – 2015; 25(20) : 41 - 57.
Podymova S.D. Intrahepatic cholestasis: pathogenesis and treatment from modern positions / Podymova S.D. // Consilium Medicum. - 2004. - 6 (2). - P. 3 - 6.
Tikhonov I.N. Recurrent cholestasis in a 16-year-old patient / Tikhonov I.N., Zharkova M.S., Maevskaya M.V. and others // Ros. magazine tour. hepatol. coloproctol. - 2016. - No. 4. – P.103 – 115.
Zimmerman Ya.S. Gastroenterology / Zimmerman Ya.S. // Guide for doctors. - 2nd ed., revised. and additional - M.: GEOTAR-media, 2015. - 816 p.Ivashkin V. A novel mutation of ATP8B1 gene in young patient with familial intrahepatic cholestasis / Ivashkin V., Tikhonov I., Maevskaya M. et al. // Hepatol Int 2016; 10 (Suppl 1): S1-S506.
Ian Gan S. Modafinil in the treatment of debilitating fatigue in primary biliary cirrhosis: a clinical experience / Ian Gan S., de Jongh M., Kapla M. M. // Dig. Dis. Sci. – 2009. – V. – 54 (10). – P. 2242–2246.
Lindor K. D. Primary Biliary Cirrhosis / Lindor K. D., Gershwin M. E., Poupon R. et al. // Hepatology. – 2009. – V. – 50 (1). – P. 291–308.
Prince M. I. Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis / Prince M. I., Burt A. D., Jones D. E. // Gut. – 2002. – V. – 50 (3). – P. 436–439.
Terg R., Coronel E., Sorda J. et al. Efficacy and safety of oral naltrexone treatment for pruritus of cholestasis, a crossover, double blind, placebo-controlled study / Terg R., Coronel E., Sorda J. et al. // J. Hepatol. – 2002. – V. – 37(6). – P. 717–722.