Keywords
Abstract
The article presents the results of studies of the reaction of 2-methyl-5-ethynylpyridine N-oxide with certain aliphatic and aromatic amines to produce pyridylacetylene amine N-oxides. 2-Methyl-5-ethylpyridine was converted by dehydrogenation to 2-methyl-5-vinylpyridine, and 2-methyl-5-ethynylpyridine was obtained by its bromination and dehydrobromination. Synthesized 2-methyl-5-ethynylpyridine N-oxide by oxidation of 2-methyl-5-ethynylpyridine with perhydrol in acetic anhydride. The synthesis of N-oxides of pyridylacetylene amines by the Mannich reaction was carried out. The influence of solvents on the yield of the final product: methanol, ethanol and n-dioxane, a catalyst, and also the duration of the reaction was studied. The structure and composition of the synthesized N-oxides of PAA were established using IR and PMR spectroscopy.
References
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