VIEW OF A PEDIATRIC NEUROLOGIST ON NEUROLEUKEMIA
Abstract
Relevance. In the structure of malignant tumors in children, 35% of cases are acute leukemias. The incidence of acute leukemia is characterized by geographical differences and varies within 2.5 - 4.7 per 100 thousand of the child population. At the same time, the frequency of complications from the nervous system in acute leukemia ranges from 5 to 30%, which can be induced by the underlying disease, as well as associated with treatment. The clinical picture is varied and depends on blast infiltration of the bone marrow and extramedullary foci, the main localization of which is the central nervous system.
References
Au W.Y., Shek T.W., Ma S.K., et al. Myeloblastoma (chloroma) in leukemia: case 2. Meningeal granulocytic sarcoma (chloroma) in essential thrombocythemia. J Clin Oncol 2000;18(23):3996-7. PMID 11099330
Bennett C.L., Berger J.R., Sartor O. et al. Progressive multi-focal leucoencephalopathy among ibrutinib-treated persons with chronic lymphocytic leukaemia. Br J Haematol 2018;180(2):301-4. PMID 27649938
Chamberlain M.C., Nolan C., Abrey L.E. Leukemic and lymphomatous meningitis: incidence, prognosis and treatment. J Neuroncol 2005;75: 71-83. PMID 16215818
Daniel D., Crawford J. Myelotoxicity from chemotherapy. Semin Oncol 2006;33: 74-85. PMID 16473646
Feinberg W.M., Swenson M.R. Cerebrovascular complications of L-asparaginase therapy. Neurology 1988;38: 127-33. PMID 3275903
Ficek K., Blamek S., Syguła D. et al. Evaluation of the late effects of CNS prophylactic treatment in childhood acute lymphoblastic leukemia(ALL) using magnetic resonance spectroscopy. Acta Neurochir . Suppl . 2010; 106:195–197.
Glass J. Neurologic complications of lymphoma and leukemia. Semin Oncol 2006;33: 342-7. PMID 16769423
Hehlmann R., Hochhaus A., Baccarani M. European LeukemiaNet. Chronic myeloid leukaemia . Lancet 2007;370: 342-50. PMID 17662883
Horowitz N., Brenner B . Thrombophilia and cancer. Pathophysiol. haemost. Thromb . 2008; 3-4: 131–136.
Ishimori M.L., Pressman B.D., Wallace D.J., Weisman M.H. Posterior reversible encephalopathy syndrome: another manifestation of CNSSLE? Lupus 2007; 16:436–443.
Laningham F.H., Kun L.E., Reddick W.E., Ogg R.J., Morris E.B., Pui C.H. Childhood central nervous system leukemia: historical perspectives, current therapy, and acute neurological sequelae. Neuroradiology 2007;49(11):873-88. PMID 17924103
Pui C.H., Evans W.E. Treatment of acute lymphoblastic leukemia. N Engl J Med 2006;354: 166-78. PMID 16407512
Pui C.H. Central nervous system disease in acute lymphoblastic leukemia: prophylaxis and treatment. Hematology Am Soc Hematol Educ Program 2006:142-6. PMID 17124053
Rogers L.R. Cerebrovascular complications in patients with cancer. Semin Neurol 2004;24: 453-60. PMID 15637656
Shah R., Bag A.K., Chapman P.R., Curé J.K. Imaging manifestations of progressive multifocal leukoencephalopathy. Clinic . Radiol . 2010; 65: 431-439.
Sul J.K., DeAngelis L.M. Neurologic complications of cancer chemotherapy. Semin Oncol 2006;33: 324-32. PMID 16769421
