Keywords
Abstract
A mechanographic study of the contractile activity of rat aortic smooth muscle cells is presented to investigate the action of 4-Amino-5-(2-aminophenyl)-2,4-dihydro-3H-1,2,4-triazolo-3-thione (D-378). Vasorelaxant effects have been demonstrated for D-115 oxadiazole and D-378 triazole. Simultaneously, it was discovered that D-378 triazole obtained by synthesis on the basis of D-115 oxadiazole with hydrosine hydrate has pronounced vasorelaxant activity. In this regard, we conducted comparative studies of the effect of D-115 oxadiazole and D-378 triazole on the contractile activity of SMCs in the rat aorta to determine the dependence of the relaxant activity of D-378 triazole on its structure.
References
Jentsch T., Hübner C., Fuhrmann J. Ion channels: Function unravelled by dysfunction. Nature Cell Biology. 2004. Vol. 6, P. 1039 – 1047.
Vascular smooth muscle contraction in hypertension Rhian M Touyz, Rheure Alves-Lopes, Francisco J Rios, Livia L. Camargo, Aikaterini Anagnostopoulou, Anders Arner, Augusto C Montezano Author Notes Cardiovascular Research, Volume 114, Issue 4, 15 March 2018, Pages 529–539, https://doi.org/10.1093/cvr/cvy023
Paul H. Ratz, Krystina M. Berg, Nicole H. Urban, and Amy S. Miner. Regulation of smooth muscle calcium sensitivity: KCl as a calcium-sensitizing stimulus// Am J Physiol Cell Physiol – 2005 V.288: P.769 –783.
Berridge M.J. Smooth muscle cell calcium activation mechanisms // Journal of Physiology. – 2008. – V.586. – P.5047–5061.
Martinsen A., Baccelli C., Navarro I., Abad A., Quetin–Leclerc J., Morel N. Vascular activity of a natural diterpene isolated from Croton zambesicus and of a structurally similar synthetic trachylobane // Vascular Pharmacology. – 2010. – V.52. – P.63–66.
Yanagisawa T and Okada Y.KCl depolarization increases Ca2+sensitivity of contractile elements in coronary arterial smooth muscle.Am J Physiol Heart Circ Physiol. 267: H614 –H621, 1994.
Nishimura K., Ota M., Ito K. Existence of two components in the tonic contraction of rat aorta mediated by alpha 1–adrenoceptor activation // British Journal of Pharmacology. – 2002. – V.102. – Р.215–221.
Taeko Kaimoto, Osamu Yasuda, Mitsuru Ohishi, Masaki Mogi, Yukihiro akemura, Toshimitsu Suhara, Toshio Ogihara, Keisuke Fukuo, Hiromi Rakugi. Nifedipine inhibits vascular smooth muscle cell dedifferentiation via downregulation of Akt signaling. Hypertension 2010 Aug;56(2):247-52.